MELAquine C1G 4% Cream

Uneven pigmentation of some sort affects most people, regardless of ethnic background or skin color. Skin may either appear lighter, or darker than normal, or lack of pigmentation at all, there maybe blotchy, uneven areas, patches of brown to gray discoloration or freckling.

Skin pigmentation disorders occur because the body produces either too much or too little melanin.

Albinism is a congenital disorder characterized by the complete or partial absence of pigments in the skim hair and eyes due to absence or defect of tyrosinase in melanin production and results from inheritance, lack of skin pigmentation and makes skin patchy and more susceptible to sunbum and skin cancers.

Vitiligo is a condition that causes depigmetation. It occurs when melanocytes, the cells responsible for skin pigmentation, die or become unable to function. Hyperpigmentation is caused by increased melanin production and may arise from epidermis, dermis or both and affects the skin color as well. Chloasma or mask of pregnancy describes skin discolo-rations caused by hormones.

These hormonal changes are usually the result of pregnancy. contraceptions or hormone replacement therapy (HRT). Possible symptoms are: irregular hyperpigmented macules to patches commonly appear on the upper cheek, nose, lips and forehead. Solar lentigo, also known as “liver spots” refers to light brown to red or black spots on the hands, face, shoulders, arms and forehead caused by aging and sun exposure.

These spots and quite common in adults with a long history of unprotected sun exposure. Apart from sun exposure and hormones, hyperpigmentation can be caused by skin damage,such as remnants of blemishes, wounds or rashes.

Human Skin Color Skin

color is due primarily to the presence of a pigment called melanin which exists naturally in epidermis. Melanin is produced within the skin in cells called melanocytes in melanogenesis process from tyrosine amino acid by means of some enzymes specially tyrosinase that is produced by pituitary gland’s hormones.

only the melanin is responsible for skin color butalso protects the skin from harmful effects of ultra violet radiation of sun light. Human skin color rang is variety from the darkest brown to the lightest pinkish-while hues. This variety is depending on genetics, aging, geographic variation and sun exposure. skin photo type depends on the amount of melanin pigment in the skin.

Treatment of Hyperpigmentation

Regarding the fact that hyperpig- mentation are caused by an excess production of melanin, the effective treatment is to inhibit the tyrosinase activity to reduce or half the overproduction of melanin. The most common active ingredients in this field are Hydroquinone, Kojic acid and Arbutin that inhibit the tyrosinase activity relatively but not completely and show inadequate efficacy as expected. Apart from low treatment effect and long lasting treatment period, these compounds may lead to skin erythema, inflammation and desquamation in some cases.

As mentioned, the signs of hyperpigmentation disorders have an influence effect on the beauty of complexion specially in women, so it is important to apply novel and more effective skin lightening products in order to inhibit and diminish the appearance of dark and brown spots are found particularly on face and hands.

Attention

Avoid contact with eyes, lesions and mucous membranes. In case of skin irritation, discontinue use and consult your physician. Keep in a cool dry place and out of reach of children and sun exposure.

Direction for Use

Since there are some special ingredients in this product, it is recommended to use it on the prescription of a practitioner as bellow: At nights, apply softly, without rubbing (friction enhances the overproduction of melanin) to the hyper pigmented areas. It is recommended to use this cream for 8 – 12 weeks to see visible results. To obtain the perfect prevention of appearance of dark spots, it is best to use Sunscreen products during treatment period.